Researchers uncovered how polyamines influence cell fate by altering protein phosphorylation and alternative splicing. The ...
Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreas cancer. It's also the most common form of the ...
Disruption of alternative splicing can generate abnormal mRNA variants, producing nonfunctional proteins or triggering ...
The Krainer lab discovered a three-oncogene circuit that helps drive the aggressive progression of pancreatic ductal ...
Researchers at CSH Laboratory identified an oncogenic SRSF1–AURKA–MYC circuit driving pancreatic ductal adenocarcinoma.
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Splicing regulator U2AF1 promotes angiogenesis in cardiac injury
A study published in Engineering shows that a protein called U2 small nuclear RNA auxiliary factor 1 (U2AF1), released by immune cells known as macrophages, helps grow new blood vessels in the heart ...
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