A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled ...

Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...

The novel biosensor technology used in this study can also be transferred to other so-called G protein-coupled receptors (GPCRs), which act as crucial “signal receivers” in our cells and are of major ...

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...

Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other ...

Triggering receptors expressed on myeloid cells (TREMs) are a cell surface receptor family found on granulocytes, monocytes, macrophages, and dendritic cells—as well as other myeloid cells in general.

Recently these monocyte-derived alveolar macrophages, or Mo-AMs, were identified as key drivers of lung fibrosis disease progression. However, the mechanisms of their pro-fibrotic behavior and ...

Scientists suggest increasing what is understood about exocytosis could one day inform many fields of applied science.

Proteomics experiments on Drosophila reveal sex-specific effects in aging, and an important role for a protein called DIP-β.

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely silence a brain receptor that pharmaceutical companies are racing to target ...