Common pain meds used by millions may increase heart disease and stroke risk

Certain common OTC painkillers have been linked to an increased risk of high blood pressure, stroke and heart attacks.
Medscape

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity

BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...

This Popular Painkiller in Your Cabinet May Be Doing More Than You Think

Ibuprofen’s anti-inflammatory action may influence cancer risk, but evidence remains complex and routine use for prevention is not advised. Ibuprofen is one of the most widely used pain relievers, ...
Kitsap Sun

Use caution with pain relievers, even when they come over-the-counter

When people think of harmful pain medications, opioids are often the first drugs that come to mind. The damage these medications can cause has been the topic of news segments, magazine articles, and ...
Medscape

Efficacy and Tolerability of Meloxicam, a COX-2 Preferential Nonsteroidal Anti-Inflammatory Drug

Meloxicam is an enolcarboxamide with preferential COX-2 inhibitory activity. In vitro studies with human tissues have confirmed the high affinity of meloxicam for COX-2, whereas COX-1 was inhibited ...