This is a preview. Log in through your library . Abstract Stimuli are translated to intracellular calcium signals via opening of inositol trisphosphate receptor and ryanodine receptor (RyR) channels ...

The steep dependence of channel opening on membrane voltage allows voltage-dependent K + channels to turn on almost like a switch. Opening is driven by the movement of gating charges that originate ...

A sensor of membrane depolarization controls the activity of a bound enzyme through a novel mechanism involving two sequential voltage-dependent transitions allosterically coupled to changes in the ...

(A) shows the conventional topology of a voltage-gated potassium channel subunit with six transmembrane domains (S1–S6). Charge carrying residues are indicated on the S4 (red) segment. (B) shows the ...

Genetically encoded voltage indicators (GEVIs) based on microbial rhodopsins utilize the voltage-sensitive fluorescence of all-trans retinal (ATR), while in electrochromic FRET (eFRET) sensors, donor ...