Have you ever wondered why endotoxin testing is crucial? Endotoxins are toxic substances found in the outer membrane of Gram-negative bacteria, and they can cause severe reactions in humans, including ...

Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

As thoroughly covered in your recent article (C&EN, Oct. 28, 2024, page 26), the issue of replacing the traditional natural product test for endotoxin, limulus amoebocyte lysate (LAL), with a ...

With the introduction of pioneering technology for bacterial endotoxins testing (BET), it is critical to demonstrate equivalency across platforms. The Sievers Eclipse Ratio Verification Test was ...

The quality of water for pharmaceutical production (purified water, water for injection, and ultrapure water) is quantified and regulated through four parameters – total organic carbon (TOC), ...

New standards may help push more drugmakers to use a synthetic product for critical drug safety testing, instead of one made from horseshoe crab blood that has long drawn criticism. The U.S.

In this episode of C&EN Uncovered, host Craig Bettenhausen speaks with C&EN assistant editor Laurel Oldach about the use of horseshoe crab blood in pharmaceutical endotoxin testing, the challenges of ...

Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a fast and cost-effective method to test liquids for a ubiquitous family of chemical ...

Charles River International Laboratories, Inc. CRL recently launched Endosafe Trillium rCR cartridges, which combine its hallmark Endosafe cartridge technology with recombinant cascade reagent (rCR).

Every year in May when high tide coincides with the full moon, horseshoe crabs convene on the beaches of the mid-Atlantic coast to lay millions of eggs. At the same time, migratory shorebirds on their ...