RCTs incorporate several methodological characteristics intended to maximize the validity of conclusions about the efficacy and safety of the intervention under study. 1 First, they employ a ...

A seminal paper by Miller and Brody [1] clearly laid the general framework on why we should abandon the term "clinical equipoise" in research. Their paper argued that the concept of equipoise (also ...

For more than a decade, the U.S. Preventive Services Task Force (USPSTF) [23] has published a ranking of clinical evidence. [24] The rankings, however, are based on what clinical investigators have ...