Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic ...
Spatial profiling provides unique opportunities to study biology in health and disease by enabling transcriptomic analysis of specific cell types or tissue compartments within their topohistological ...
The heart is able to adapt to changing conditions and demands by using a molecular mechanism known as alternative splicing.
A team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain. This novel dataset provides ...
Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could help scientists analyze genetic data with greater ...
The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi pathway. When miRNA acts as the guide for RNAi, only a ...
Researchers uncovered 214,516 unique isoforms in the developing neocortex -- over 70% of which have not been previously studied. A team led by researchers at UCLA and the University of Pennsylvania ...
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