Swedish researchers have identified genetic variants that increase the risk of atherosclerosis. The aim is for these new findings to enable earlier detection of atherosclerosis and improved treatment ...

Our understanding of human metabolism is mostly based on dedicated hypothesis testing in experimental settings, informed by model organisms or observations in patients with rare diseases. Only ...

For decades, geneticists have known that most common illnesses are not caused by a single rogue gene but by intricate constellations of DNA variants acting together in specific cells. Now a new ...

Translating genome-wide association study (GWAS) loci into causal variants and genes requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues. Building enhancer–gene maps ...

Rare genetic traits are features that are uncommon within the general population. They can lead to different observable features or to rare physical abilities. Rare genetic traits are typically ...

An international collaboration of genetic researchers has identified more than 90 genetic regions associated with the risk of Alzheimer's disease and related dementias. The large-scale meta-analysis ...