DNTH212 is a bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress B cell ...

The regulation of type I interferon (IFN-1) signaling is crucial for fine-tuning the innate immune response to combat pathogens, fight cancer and prevent autoimmune diseases. Disrupted IFN-1 signaling ...

The authoritative peer-reviewed source for research, analysis, and advances on the therapeutic role of cytokines and IFNs. Suppressor of Cytokine Signaling (SOCS) 1 is a key negative regulator of ...

Interferon-Free Treatment: No Longer a Dream? Several studies were presented at both Digestive Disease Week (DDW) 2012 in May and at the European Association for the Study of the Liver (EASL) annual ...

Researchers have long focused on the Stimulator of Interferon Genes (STING) pathway, a key component of the innate immune system, as an approach to recruit immune cells to target cancer. However, ...

KUALA LUMPUR, Malaysia — A new interferon-free drug regimen for the treatment of hepatitis C is safe and effective in treatment-naïve patients and in those who previously had a poor response to ...

Targeted inhibition of a "signal jammer" protein may improve how tumors respond to immunotherapy. Published today in Nature, a new study demonstrates how some cancer cells use the protein ...