Quantitative oblique back-illumination microscopy (qOBM) has emerged as a powerful technique for label-free, 3D quantitative phase imaging of arbitrarily thick biological specimens. However, in its ...

Quantitative phase microscopy (QPM) leverages forward-scattered light and can detect structures at the microscale (in this study, over 100 nanometers), but not smaller. Consequently, this technique ...

Optical imaging techniques have been indispensable tools for investigating living systems for many centuries. The ability to image biological systems in high resolution over space and time would allow ...

Image by the US National Institutes of Health, CC 3.0 A new dual-light microscope lets researchers observe micro- and nanoscale activity inside living cells without using dyes. The system, from the ...

Light waves, as they propagate through a medium, experience a temporal delay. This delay can unveil crucial information about the underlying structural and compositional characteristics. Quantitative ...

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...

For decades, imaging weakly scattering phase objects such as cells has been an active area of research across various fields, including biomedical sciences. One common approach uses chemical stains or ...

Early diagnosis and noninvasive monitoring of neurological disorders require sensitivity to elusive cellular-level alterations that emerge much earlier than volumetric changes observable with ...

Conceptual illustration of the bidirectional quantitative scattering microscope, which detects both forward and backward scattered light from cells. This dual detection enables visualization of ...