Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...
For patients who have chronic lymphocytic leukemia (CLL), experiencing Richter transformation with central nervous system ...
Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...
Dr Garcia-Manero discusses the effects of TP53 mutation in patients with MDS. I don’t have an answer to your question. We don’t understand why this has become so refractory to therapies. It’s like ...
A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the ...
In a recent study published in Nature Genetics, researchers performed an allelic-level single-cellular multi-omics evaluation of hematopoietic stem/progenitor cells (HSPCs) obtained from individuals ...
BUFFALO, NY- October 11, 2024 – A new editorial was published in Oncotarget's Volume 15 on October 1, 2024, entitled, “Transplant or no transplant for TP53 mutated AML.” As highlighted in this ...
What is Li-Fraumeni syndrome? Li-Fraumeni syndrome (LFS) is a genetic condition that increases the risk of developing many different types of cancers. What causes Li-Fraumeni syndrome? LFS is caused ...
Patients with TP53 germline variants have an increased risk of secondary sarcoma post-radiation therapy. The 15-year risk of sarcoma for TP53 pathogenic variant carriers is 8.8%, higher than the ...
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