The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, ...

The quest for longevity and vitality has captivated humanity for millennia, but only in recent decades has science begun to unravel the biological mechanisms underlying ageing. Today’s anti-ageing ...

Longer leukocyte telomere length is associated with higher left ventricular mass (LVM) and larger global ventricular size, as well as better cardiac function and lower risk of heart failure (HF). The ...

The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, ...

Telomere shortening is a potential diagnostic tool for differentiating ILD types, particularly in idiopathic pulmonary fibrosis (IPF). Genetic mutations in telomerase genes, such as TERC and TERT, ...

Heritable pathogenic defects in genes related to mitosis and telomere function may specifically increase the risk for sarcomas – rare cancers that develop in muscles, bones, and other connective ...

Much the way the caps on the ends of a shoelace prevent it from fraying, telomeres - regions of repetitive DNA sequences and a protein structure - protect the tips of chromosomes from damage. Every ...

New findings describe how the enzyme CST is recruited to the end of the telomere, where it maintains telomere length with the help of subtle chemical changes made to the protein POT1. The length of ...

CST (purple/lavender) bound to POT1 (red). Phosphorylation of the crimson-highlighted region in POT1 regulates the recruitment and activity of CST–Polα-primase at telomeres. The length of telomeres ...