A team led by UT Southwestern Medical Center researchers has uncovered a molecular pathway that links obesity to widespread ...

Cascades of signals are transduced when, for example, a hormone meets its receptor, when one cell touches another, or when a lymphocyte contacts its cognate antigen. Many steps in these pathways ...

Plant phototropism—directional growth in response to light—serves as a key adaptive mechanism, optimizing photosynthesis and development. Central to this process is phototropin 1 (phot1), a primary ...

Multiple studies have demonstrated the memory-enhancing effects of melatonin and its derivatives in animal models. It is also known that the formation of both short- and long-term memories require the ...

Photys Therapeutics has debuted with $75 million in series A financing to develop phosphorylation-inducing chimeric small molecules (PHICs) to treat disease. PHICs are two-ended molecules that draw ...

BOSTON--(BUSINESS WIRE)--Photys Therapeutics, the pioneer in the development of phosphorylation-inducing chimeric small molecule medicines (PHICS), founded by Longwood Fund and Dr. Amit Choudhary of ...

Phosphorylation of α-synuclein at serine 129 has long been used as a marker of synucleinopathy—p-S129syn accumulates in Lewy bodies, after all. But does this modification have a physiological function ...

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...