Members of a new class of antivirals are being tested in U.S. clinical trials, and one has gained approval in Japan, but how ...

Researchers use cryo-EM and optical tweezers to investigate how an antiviral interacts with the herpes simplex virus.

Harvard Medical School researchers have uncovered crucial insights into how an emerging class of antiviral drugs works.

Primases are essential RNA polymerases required for the initiation of DNA replication, lagging strand synthesis and replication restart. Many aspects of primase function remain unclear, including how ...

– Data from both ABI-5366 and ABI-1179, novel long-acting helicase-primase inhibitor candidates for recurrent genital herpes, to be presented – – Poster presentation highlights key preclinical data ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 40 (October 1, 2013), pp. 15961-15966 (6 pages) Initiation of DNA synthesis in genomic duplication ...

Emerging evidence suggests that Cdc13-Stn1-Ten1 (CST), an RPA-like ssDNA-binding complex, may regulate primase-Pol α (PP) activity at telomeres constitutively, and at other genomic locations under ...

March 21, 2012 (San Diego, California) — A novel helicase-primase inhibitor with antiviral activity against the varicella zoster virus might provide an alternative as potent as current treatments for ...

Replication of DNA requires helicase and primase activities as part of a primosome assembly. In bacteriophage T4, helicase and primase are separate polypeptides for which little structural information ...

The herpes simplex virus (HSV) causes cold sores and genital lesions and with the exception of acyclovir (an inhibitor of the viral DNA polymerase), there are currently no drug treatments available.