An increasing amount of research indicates that more translational and appropriate observations can be made with organoids and micro-tissues in comparison with 2D monolayer cell models. This is most ...

Drastic differences in the ways cells behave and respond to drugs are observed when cells are cultured using 3D instead of 2D approaches. These differences are driving the adoption of more advanced ...

Evaluating Anticancer Drugs and Building Tissue and Tumor Co-Culture Models Among Uses The need for new tools and technologies to decrease the cost of drug discovery and reduce animal testing has been ...

The utilization of multi-cell tumor spheroids as an oncology research model has quickly increased because of a greater understanding of the effects of the tumor microenvironment, along with the ...

This presentation highlights a 5-step outline for the development of a 3D spheroid model using breast cancer as an example. These guidelines can be extrapolated to cells of other cancer types as well.

As researchers demand more physiologically relevant in vitro models, 3D spheroid cultures have emerged as powerful tools in drug discovery and disease modeling. Yet despite their promise, many 3D ...

Isolation of spheroid-forming cells is important to investigate cancer stem cell (CSC) characteristics. However, conventional tumor spheroid culture methods have not proven suitable because the ...

Galaxies in the Universe exhibit a variety of shapes and can be broadly classified into two categories. The first category includes younger, disk-like spiral galaxies, such as the Milky Way, which are ...