The JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death, and tumor formation.

Aug 21, 2024 · In this review, we outline the structural basis that governs key nodes in this pathway, offering a comprehensive overview of the signal transduction process. Furthermore, …

Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge …

Feb 23, 2023 · In this review, we discuss the role of the JAK/STAT pathway in mechanistic signaling, disease progression, immune environment, and therapeutic targets.

Aug 1, 2025 · Among these sophisticated pathways, JAK-STAT signaling stands out as a fundamental mechanism. This pathway acts as a rapid conduit, transmitting external signals …

The JAK-STAT signaling pathway is defined as a cytokine-stimulated signaling pathway involved in various biological processes, including cell proliferation, differentiation, apoptosis, and …

The JAK/STAT cascade is among the sim-plest of the conserved metazoan signaling pathways. The binding of extracellular ligand leads to pathway activation via changes to the receptors …

The JAK-STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription and expression of genes involved in immunity, …

JAK/STAT is a pivotal signal transduction pathway driving cellular responses such as proliferation, migration, differentiation, angiogenesis, and apoptosis. This pathway is central to homeostasis …

Nov 26, 2021 · In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway.